Molecular Parasitology

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The Siegel Lab

The Siegel Lab is interested in the molecular mechanisms underlying antigenic variation in Trypanosoma brucei. We are specifically interested in how changes in chromatin structure and 3D genome architecture affect antigen expression.

We have established numerous system-wide approaches in T. brucei, including ribosome-profiling, high-resolution ChIP-seq and Hi-C technology as well as a mass spectrometry-based approach to quantify levels of histone acetylation. Using these techniques, we investigate how different chromatin structures are established at specific loci along the genome, how the genome is organized in 3D across the nucleus and how this affects gene expression.

We are part of the Faculty of Veterinary Medicine and associated with the Chair of Experimental Parasitology (Markus Meissner). Our lab is located at the Chair of Physiological Chemistry (Andreas Ladurner) at the Biomedical Center Munich (BMC).

The Siegel Lab has received funding from the following sources:


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