Molecular Parasitology
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Our most complete and most accurate 427 Lister diploid genome assembly

The peer-reviewed version is now online

16.09.2021

 genome_phased

 

Using long-read sequencing and Hi-C data Raúl was able to put together the first, full allele-specific genome assembly of the diploid parasite Trypanosoma brucei. We are cetain the new assembly will open the door to study allelic gene expression heterogeneity.

Cosentino RO*, Brink BG, Siegel TN* (2021)
Allele-specific assembly of a eukaryotic genome corrects apparent frameshifts and reveals a lack of nonsense-mediated mRNA decay
NAR Genomics and Bioinformatics doi.org/10.1093/nargab/lqab082

* corresponding authors
members of the Siegel lab are listed in bold